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Alpha-casein

  1. Precision Fermentation
  2. Proteins
  3. Dairy - Caseins
  4. Alpha-casein

    Technical Data

    Type of Protein Dairy - Caseins
    Protein name Alpha-casein
    Companies producing this protein Made in combination with other caseins (see general casein companies)
    Function (dairy alternative, colorant, texture, taste...) Dairy alternative (Chezan et al., 2025)
    Target application (cheese, infant formula, meat...) Cheese, milk, yogurt & other dairy products (Chezan et al., 2025)
    Purity requirement/purification values Has been isolated at >90% purity in a patent (Lanquar et al., 2024)
    Techno-functional properties Improves viscosity, structure and texture. Gelling emulsifying and foaming properties (Broyard & Gaucheron, 2015)
    Nutritional properties Binds metal ions, facilitating the absorption of essential nutrients, and is the precursor of bioactive peptides that regulate important physiological functions (Knychala et al., 2024)
    Advantages Their techno-functional properties make caseins perfect for animal-free cheese production (Hettinga & Bijl, 2022).
    Challenges/risk factors
    • PTMs (both glycosylation and phophorylation) play a huge role in the folding and function of caseins. Different PTM patterns in non-mammalian host strains might impact the folding and function of caseins (Hettinga & Bijl, 2022).
    • Potential allergenicity (Hochwallner et al., 2014)
    Bacillus subtilis
    Komagatella phaffi (Pichia pastoris)
    Escherichia coli

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